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Various types of cancers have been identified which affects different organs and they are broadly grouped under the category of carcinoma, sarcoma, lymphoma or leukemia based on the type of tissue origin. common striking features of all types of cancer is uncontrolled cell proliferation, antiapoptosis, enhanced angiogenesis, genomic instability and metastasis.
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The broad range of devastating characteristics of the cancer makes it a very good therapeutic target for designing the small molecules. In cancer drug discovery programme, researchers have contributed many novel synthetic compounds as anticancer drugs.
Benzimidazoles are the most prominent heterocycles with …show more content…
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Multiple previous reports have suggested that benzimidazoles to be very good cytotoxic agents against different types of cancer cell lines.
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Recently bisbenzimidazole conjugates have been reported to target mitochondria in cancer cells and induce their antiproliferative activity by caspase
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dependent apoptosis.
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