Inflammation is one the common and irritating responses that occurs automatically in the body as a means of bringing the body to homeostasis. No matter how negative the response is connoted by a person it is actually a positive feedback used by the body when there is an invasion. Inflammatory responses can be local or systemic, but the later could end up being a fatal one if not taken care of. As an innate response, when the skin barrier is breached or there is an inhalation of histamine or pathogen (any foreign material), the is a quick response which occurs in two parts. The initial response occurs when soluble proteins and cell-surface receptors bind to either the foreign substance or its derivatives, or to human cells and serum proteins
