The Zika virus infection’s diagnosis has been a herculean task. The Zika virus disease infection symptoms can easily be confused with those of another arbovirus - induced diseases due to its non-specificity. Therefore, the differential diagnosis is important. In vitro detection of ZKIV can be done by detection of virus, viral nucleic acid, viral antigen, or antibody or by a collaboration of these techniques. However, the method of detection is decided on the basis of detection required such as clinical, epidemiological study, or vaccine development. Moreover, the type of laboratory facilities and expertise available is also a matter of concern prior to initialization detection. A test for the detection of viral or nucleic acid was done after
