Introduction / 5p- 1200w
The most frequent cause of sudden cardiac death is hypertrophic cardiomyopathy (HCM), mainly in young people. It is characterized by thickening in the left ventricle (LV) wall not related to load condition such as aortic stenosis or systemic hypertension (Bing, Knott et al. 2000). It is estimated that approximately one in 500-1000 population. HCM is a complex genetic inherited cardiovascular disease caused by dominate mutation in coding of cardiac sarcomere proteins gene (Maron, Maron et al. 2012). The potential clinical outcomes of the disease are significantly heterogeneous including heart failure at young age and sudden cardiac death (SCD) in absence of any alarming symptoms (Semsarian, Ingles et al. 2015).
increase the wall thickening in LV walls and loose connective tissue consider the main structural and functional myocardial abnormalities in HCM subjects. (Varnava, Elliott et al. 2000). Several studies have been shown that fibre disarray and myocardial fibrotic lesions a have high contribution in heart …show more content…
Whereas, hypertensive left ventricle hypertrophy (H-LVH) is accompanied with symmetrical concentric hypertrophy of the left ventricle. However, it has been reported that 31% of patients with HCM have concentric hypertrophy, and 4-47% with H-LVH have ASH. Therefore, differentiate between HCM and H-LVH based on morphological imaging findings can be challenging.(Grossman, Jones et al. 1975, Dunn, Chandraratna et al. 1977)
2DST is relatively new advanced technique, many studies report that 2DST has the potential to demonstrate regional cardiac contractile function and has the ability to characterise the intermural deformation in HCM patients.(Serri, Reant et al. 2006). However, the utility of 2DST to distinguish HCM from other form of LVH has not been fully studied.
Imaging techniques in
The most frequent cause of sudden cardiac death is hypertrophic cardiomyopathy (HCM), mainly in young people. It is characterized by thickening in the left ventricle (LV) wall not related to load condition such as aortic stenosis or systemic hypertension (Bing, Knott et al. 2000). It is estimated that approximately one in 500-1000 population. HCM is a complex genetic inherited cardiovascular disease caused by dominate mutation in coding of cardiac sarcomere proteins gene (Maron, Maron et al. 2012). The potential clinical outcomes of the disease are significantly heterogeneous including heart failure at young age and sudden cardiac death (SCD) in absence of any alarming symptoms (Semsarian, Ingles et al. 2015).
increase the wall thickening in LV walls and loose connective tissue consider the main structural and functional myocardial abnormalities in HCM subjects. (Varnava, Elliott et al. 2000). Several studies have been shown that fibre disarray and myocardial fibrotic lesions a have high contribution in heart …show more content…
Whereas, hypertensive left ventricle hypertrophy (H-LVH) is accompanied with symmetrical concentric hypertrophy of the left ventricle. However, it has been reported that 31% of patients with HCM have concentric hypertrophy, and 4-47% with H-LVH have ASH. Therefore, differentiate between HCM and H-LVH based on morphological imaging findings can be challenging.(Grossman, Jones et al. 1975, Dunn, Chandraratna et al. 1977)
2DST is relatively new advanced technique, many studies report that 2DST has the potential to demonstrate regional cardiac contractile function and has the ability to characterise the intermural deformation in HCM patients.(Serri, Reant et al. 2006). However, the utility of 2DST to distinguish HCM from other form of LVH has not been fully studied.
Imaging techniques in