1. One of the main topics could be the drug resistance mechanisms of bacteria.
2. First, spontaneous mutation which changes the drug target or upregulate drug efflux. Second, Horizontal gene transfer (HGT) that the genes in bacteria acquire to become resistant. HGT can cause multidrug resistance in a genetic event which make the bacteria become resistance. Third, the ability of bacteria that they can form biofilm while they are being infected. The bacteria provide themselves protection to against the drug therapy physically and physiologically. Also, duplication or amplification of genome’ parts that recombines the repeated sequences in genome and can cause resistance to the bacteria.
3. It came from a secondary source.
4. First, the paragraph
2. First, spontaneous mutation which changes the drug target or upregulate drug efflux. Second, Horizontal gene transfer (HGT) that the genes in bacteria acquire to become resistant. HGT can cause multidrug resistance in a genetic event which make the bacteria become resistance. Third, the ability of bacteria that they can form biofilm while they are being infected. The bacteria provide themselves protection to against the drug therapy physically and physiologically. Also, duplication or amplification of genome’ parts that recombines the repeated sequences in genome and can cause resistance to the bacteria.
3. It came from a secondary source.
4. First, the paragraph