Funtional Organizational Behavior Analysis

Funtional organization is defined as the principle of specialization based on function or role. So, when discussing functional organization it is my understanding that this concept refers to the idea that regions communicate based on a larger goal (the brain works together in ways that make sense in coordination with the person’s actions and thought processes).The functional organization of the brain is best categorized as a flexible, but constrained network of interrelated regions. That being said, it may be interesting to examine what occurs when the brain is not operating functionally. So, in this paper I will review literature about the development of functional organization as well as 2 situations in which functional connectivity is altered …show more content…
looked at how age impacted functional connectivity through the comparison of early and late-onset AD patients to 2 age-matched groups (young and old). The differences in functional connectivity were examined through resting state fMRI comparisons on 20 early-onset (65 years) AD patients, and 15 “young” (65 years) age matched control groups. The differences in connectivity were examined through 8 resting state networks and 5 cognitive domains[1]. They found that early-onset AD patients showed lower functional connectivity compared to the “young” age-matched controls in all 8 RSNs and late-onset AD patients showed lower functional connectivity compared to the “old” age-matched controls in 2 of the 8 RSNs. Functional connectivity was lower in early-onset compared to late-onset AD in auditory-, sensory-motor, dorsal-visual systems and the default mode network. Overall they came to the conclusion that functional organization was more disrupted in early-onset AD patients when compared with late-onset AD patients. However, they warned that the sample from this study was small and from similar locations so it really wasn’t meant to be seen as a trend across all Alzheimer’s