Case Summary, including Signs and Symptoms This case study aimed to shed light on the importance of rapid detection of microorganisms using an efficient technological development, Matrix-assisted laser desorption ionization, Time-of-flight and Mass spectrometry (MALDI-TOF MS). The case involved a 54 year old Asian male who had received a living-donor kidney transplant 14 years ago due to IgA nephropathy. Signs and symptoms included, fever, multifocal cellulitis, bacteremia, swelling and spontaneous pain in arms and legs (1). MALDI-TOF MS was used to identify the agent of the infection as Helicobacter cinaedi. Another method, gyrase subunit B-targeted PCR assay, was performed to confirm the identity of the organism. The authors concluded that
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cinaedi infection. Cellulitis is an inflammation of the skin and subcutaneous tissues (6). Staphylococcus aureus is a common culprit of this inflammation. The cellulitis in this case was multifocal and presented with a salmon-pink skin discoloration on the left leg of the patient (1). Swelling and spontaneous pain that began at this site eventually spread to other parts of the patient’s arms and legs. The patient was admitted with a fever of 39 °C (102.2° F). A positive blood culture confirmed the bacteremia that accompanies a H. cinaedi infection. The patient also experienced chronic diarrhea two weeks before his admission into the …show more content…
During the first two weeks, the patient received ampicillin-sublactam intravenously (1). Ampicillin is a derivative of penicillin. It works by binding to bacterial cell wall and leading to bacterial death. Sublactam works in conjunction with ampicillin by increasing the drug’s resistance to beta-lactamase. Use is indicated in cases of skin and skin structure infections (8). In the four remaining weeks, the patient received levofloxacin orally. Levofloxacin works by inhibiting DNA gyrase in bacteria, therefore preventing the bacteria from multiplying
cinaedi infection. Cellulitis is an inflammation of the skin and subcutaneous tissues (6). Staphylococcus aureus is a common culprit of this inflammation. The cellulitis in this case was multifocal and presented with a salmon-pink skin discoloration on the left leg of the patient (1). Swelling and spontaneous pain that began at this site eventually spread to other parts of the patient’s arms and legs. The patient was admitted with a fever of 39 °C (102.2° F). A positive blood culture confirmed the bacteremia that accompanies a H. cinaedi infection. The patient also experienced chronic diarrhea two weeks before his admission into the …show more content…
During the first two weeks, the patient received ampicillin-sublactam intravenously (1). Ampicillin is a derivative of penicillin. It works by binding to bacterial cell wall and leading to bacterial death. Sublactam works in conjunction with ampicillin by increasing the drug’s resistance to beta-lactamase. Use is indicated in cases of skin and skin structure infections (8). In the four remaining weeks, the patient received levofloxacin orally. Levofloxacin works by inhibiting DNA gyrase in bacteria, therefore preventing the bacteria from multiplying