Hallucinogens are a chemical substance that causes hallucinations. Hallucinations, derived from Latin, álucinari, means to ‘wander in the mind.’ Hallucinations includes all sensory perceptions whether real or not. Psychedelics, Greek derived, translates to ‘soul and mind manifesting’ and are a class of hallucinogens that are useful tools in gaining understanding of how the brain, mind and body works. The study is complex and requires a broad and deep knowledge of the various mechanisms and interactions of neurons at a molecular and cellular level. Recent studies using the Default Mode Network (DMN) give potential findings, at a neural network level. Further studies to establish the anatomical and com-putational functioning are needed (R.B.
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It is then actively transported through the blood brain barrier (BBB) into the central nervous system. From here DMT enters synaptic vesicles through serotonin transporters (SERT), via vesicular monoamine transporter 2 (VMAT2), for up to seven days. Sigma-1 receptors are located in-side the presynaptic endoplasmic reticulum (ER) which regulates calcium ion flow lead-ing to change of gradients in sodium and po-tassium channels with its binding. This caus-es a signal transduction by depolarizing and hyperpolarization triggering an action poten-tial to move through the synapse, open-ing/closing, excitatory/inhibitory, leading to binding on voltage gated receptors, like G-proteins, second messengers and membrane bound effector proteins, coupled with Guano-sine triphosphate- GTP for RNA synthesis. Figure 3, taken from Kanesha Laboratories, illustrates the complex, however incomplete, interactions involved. DMT interaction has been added to show how the reuptake pro-teins create excitatory/inhibition, ago-nist/antagonist
It is then actively transported through the blood brain barrier (BBB) into the central nervous system. From here DMT enters synaptic vesicles through serotonin transporters (SERT), via vesicular monoamine transporter 2 (VMAT2), for up to seven days. Sigma-1 receptors are located in-side the presynaptic endoplasmic reticulum (ER) which regulates calcium ion flow lead-ing to change of gradients in sodium and po-tassium channels with its binding. This caus-es a signal transduction by depolarizing and hyperpolarization triggering an action poten-tial to move through the synapse, open-ing/closing, excitatory/inhibitory, leading to binding on voltage gated receptors, like G-proteins, second messengers and membrane bound effector proteins, coupled with Guano-sine triphosphate- GTP for RNA synthesis. Figure 3, taken from Kanesha Laboratories, illustrates the complex, however incomplete, interactions involved. DMT interaction has been added to show how the reuptake pro-teins create excitatory/inhibition, ago-nist/antagonist