H. pylori is known as a main pathogenic factor in humans which cause in active chronic inflammation and induce gastric mucosal disorders. More than 50% of the world’s human population is frequently infected with this bacteria with or without any symptoms(19). Also there are variations in H. pylori prevalence in different countries. H. pylori virulence factors and infection is a source for creating of free radicals. Previous reports have shown that there was a relation between H. pylori infection and generation of ROS in infected area. Cellular glutathione concentrations in cells may reduce by several causes such as H. pylori infection and the cells can release the reactive oxygen species (ROS). Oxidative stress can induce the serum 8-OHdG level
