Gorham-Stout Syndrome: The Case Of Osteolysis

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Osteolysis, also known as “disappearing bone disease,” is a condition where parts of your skeleton begin to disappear and is usually a side effect of another underlying cause taking place in your body. Osteolysis tends to be idiopathic which means it came about spontaneously and the cause is undiscovered. The first case of Osteolysis was reported in 1838 in which an 18 year old man’s humerus disappeared completely. It disappeared over a course of 11 years, in which he suffered two fractures to the bone. The man was still able to perform life sustaining activities up until his death at age 70. The Gorham-Stout syndrome acts as a severe case of idiopathic Osteolysis of either a single bone, or bones that are touching, without regarding the joint cavities. Fractures are very likely and the bone does not recover even when the Osteolysis stops progressing. Each case of Gorham-Stout syndrome has differed in many ways. Gorham-Stout syndrome has been said to resemble a condition called “patchy osteoporosis.” It slowly progresses while shrinking the shaft of the bone, and reducing the size of the involved end. The bone affected disappears completely unless spontaneous recovery occurs, which is very unlikely. Bone scans can usually detect the disease and fractures seldom heal as it progresses through the bone. Gorham-Stout syndrome …show more content…
In 1955 several cases were released that consisted of blood vessels which were blamed for most of the damage done to the bone. None of the cases has osteoclasts. Some scientist believed that a minor fall could damage the bone so severely that is causes a lesion and eventually deteriorates. However, in most cases presented most of the bone damage was done because of an excessive amount of osteoclasts. An osteoclast is the only cell that can resorb bone and any defect of one can lead to idiopathic

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