Impact of feeding Glycyrrhiza glabra water extract on the plasma lipid profile
The levels of plasma triacylglycerols (TAG) and total cholesterol (TC) in rats during different periods of the experiment are shown in table 2. A significant decrease in both TAG and TC levels was observed in animals administered Glycyrrhiza glabra water extract. After 60 days, the Glycyrrhiza glabra water extract -supplemented diets significantly decreased plasma TAG (74 , 82, and 120 vs. 188) as calculated in mg/dl (table 2) for HFD /400mg Glycyrrhiza glabra water extract , HFD /250 Glycyrrhiza glabra water extract and 150 mg Glycyrrhiza glabra water extract vs. the HFD/group, respectively. Moreover, remarkable reduction was observed in the levels of TC at the …show more content…
Accumulation of LDL-C within the arterial wall appears to play a crucial role in the initiation and progression of atherosclerotic plaque. The concentration of LDL-C decreased while that of HDL cholesterol was increased in the experimental groups fed Glycyrrhiza glabra water extract (table 3) At the end of the feeding period (60 days), the Glycyrrhiza glabra water extract supplemented diets significantly increased the level of HDL-cholesterol (45, 45, and 52 vs. 28) as calculated in mg/dl for HFD /400mg Glycyrrhiza glabra water extract , HFD /250 Glycyrrhiza glabra water extract and 150 mg Glycyrrhiza glabra water extract vs. the control /group, respectively. As presented in table 2, the highest increase in HDL-C was measured in the group that was fed 150 mg Glycyrrhiza glabra water extract .Moreover, remarkable reduction was observed in the levels of LDL-C at the end of the experiment (table 3), as calculated in mg/dl (28, 33, and 41 vs. 139) for HFD /400mg Glycyrrhiza glabra water extract , HFD /250 Glycyrrhiza glabra water extract and 150 mg Glycyrrhiza glabra water extract vs. the control /group, …show more content…
Beta-sitosterol from glycyrrhiza glabra roots reduced intracellular levels of triglyceride and cholesterol in L6 cells.Benefical effects of beta-sitosterol on lipid metabolismIn L6 myotube cells are mediated by AM-activated protein kinase (Seung et al., 2008).Glabirdin from glycyrrhiza glabra roots showed inhibitory effect on adipogenesis in a dose dependent manner.The inhibitory effects of glabirdin resulted from inhibiting the induction of transcription factor CAAAT enhancer binding protein alpha and PPAR gamma (Jiyun et al.,
The levels of plasma triacylglycerols (TAG) and total cholesterol (TC) in rats during different periods of the experiment are shown in table 2. A significant decrease in both TAG and TC levels was observed in animals administered Glycyrrhiza glabra water extract. After 60 days, the Glycyrrhiza glabra water extract -supplemented diets significantly decreased plasma TAG (74 , 82, and 120 vs. 188) as calculated in mg/dl (table 2) for HFD /400mg Glycyrrhiza glabra water extract , HFD /250 Glycyrrhiza glabra water extract and 150 mg Glycyrrhiza glabra water extract vs. the HFD/group, respectively. Moreover, remarkable reduction was observed in the levels of TC at the …show more content…
Accumulation of LDL-C within the arterial wall appears to play a crucial role in the initiation and progression of atherosclerotic plaque. The concentration of LDL-C decreased while that of HDL cholesterol was increased in the experimental groups fed Glycyrrhiza glabra water extract (table 3) At the end of the feeding period (60 days), the Glycyrrhiza glabra water extract supplemented diets significantly increased the level of HDL-cholesterol (45, 45, and 52 vs. 28) as calculated in mg/dl for HFD /400mg Glycyrrhiza glabra water extract , HFD /250 Glycyrrhiza glabra water extract and 150 mg Glycyrrhiza glabra water extract vs. the control /group, respectively. As presented in table 2, the highest increase in HDL-C was measured in the group that was fed 150 mg Glycyrrhiza glabra water extract .Moreover, remarkable reduction was observed in the levels of LDL-C at the end of the experiment (table 3), as calculated in mg/dl (28, 33, and 41 vs. 139) for HFD /400mg Glycyrrhiza glabra water extract , HFD /250 Glycyrrhiza glabra water extract and 150 mg Glycyrrhiza glabra water extract vs. the control /group, …show more content…
Beta-sitosterol from glycyrrhiza glabra roots reduced intracellular levels of triglyceride and cholesterol in L6 cells.Benefical effects of beta-sitosterol on lipid metabolismIn L6 myotube cells are mediated by AM-activated protein kinase (Seung et al., 2008).Glabirdin from glycyrrhiza glabra roots showed inhibitory effect on adipogenesis in a dose dependent manner.The inhibitory effects of glabirdin resulted from inhibiting the induction of transcription factor CAAAT enhancer binding protein alpha and PPAR gamma (Jiyun et al.,