The elevation of MDA levels is a result of a hyperglycaemic state that induces the overproduction of oxygen free radicals in diabetes.14 Hyperglycemia can induce oxidative stress through different pathways such as activation of protein kinase C, polyol and hexosamine pathways and advanced glycation end products production. All of these together , in association to hyperglycemia-induced dysfunction of mitochondrial and endoplasmic reticulum stress, promote reactive oxygen species (ROS)generation this in turn, promote cellular damage and contribute to the diabetic complications development and progression15.
Glutathione peroxidase is an enzyme that is found in the cytoplasm, mitochondria, and nucleus. Glutathione peroxidase metabolizes hydrogen
Glutathione peroxidase is an enzyme that is found in the cytoplasm, mitochondria, and nucleus. Glutathione peroxidase metabolizes hydrogen