Soft tissue giant cell tumor (GCT-ST) of low malignant potential is an uncommon neoplasm, considered the soft tissue counterpart of giant cell tumor of bone. The age range of patients with primary GCT of soft tissue is 1-86 yrs with female predominance of 3:2 GCT- ST manly affects young to middle – age adults & presents as a painless growing mass mainly located in the lower extremities and hunk (2,3,4,5). The majority of these tumors is located superficially (in subcutaneous tissue) and occur in the proximal parts of the extremities. Complete excision with negative surgical margins is associated with a benign clinical course in most cases (6).
Case report:- A 46 yrs old male presented with a painless mass in the left lateral neck …show more content…
More recently, Flope et al (7) proposed the term of giant cell tumor of low malignant potential. Approximately, 70 cases of GCT – ST have been described in the literature (8-11) have been described in the thigh, trunk & upper extremities and rarely in the head and neck (12). Histologically, GCT – ST is similar to its bony counterpart demonstrating a mixture of mononuclear cells with round to oval nuclei and osteoclast like multinucleated giant cells. Metaplastic bone formation at the periphery of the lesion is observed in 40 – 50% of cases (9) cystic changes, are present in approximately 30% of tumors (10). Foci of necrosis are very rare and cytological atypia is absent even if there is a high mitotic activity and vascular invasion (7).
Histopathologically GCT – ST should be separated from other tumors which can also show prominent giant cell component such as giant cell tumor of tendon sheath, extraskeletal osteosarcoma, or other benign reactive processes containing abundant osteoclast like giant cells (2). Malignant GCT – ST is extremely rare, characterized by nuclear atypia, Pleomorphism and atypical abundant mitosis (1). Local recurrence has been described after incomplete surgical excision though metastases are extremely rare
Case report:- A 46 yrs old male presented with a painless mass in the left lateral neck …show more content…
More recently, Flope et al (7) proposed the term of giant cell tumor of low malignant potential. Approximately, 70 cases of GCT – ST have been described in the literature (8-11) have been described in the thigh, trunk & upper extremities and rarely in the head and neck (12). Histologically, GCT – ST is similar to its bony counterpart demonstrating a mixture of mononuclear cells with round to oval nuclei and osteoclast like multinucleated giant cells. Metaplastic bone formation at the periphery of the lesion is observed in 40 – 50% of cases (9) cystic changes, are present in approximately 30% of tumors (10). Foci of necrosis are very rare and cytological atypia is absent even if there is a high mitotic activity and vascular invasion (7).
Histopathologically GCT – ST should be separated from other tumors which can also show prominent giant cell component such as giant cell tumor of tendon sheath, extraskeletal osteosarcoma, or other benign reactive processes containing abundant osteoclast like giant cells (2). Malignant GCT – ST is extremely rare, characterized by nuclear atypia, Pleomorphism and atypical abundant mitosis (1). Local recurrence has been described after incomplete surgical excision though metastases are extremely rare