Medicine has come a long way from blood sucking leeches of the 1700’s to the modern vaccination today. With the introduction to the world of nanotechnology in the 21st century, medicine and treatments have taken major leaps forward. Scientists have managed to theorize a new method in which to battle cancer with the help of nanomedicine. Instead of the separating 2 treatments, there is a theory in research that argues for the benefits combining them into a single nano-carrier which would support one another for effective treatment. What are these two methods? Gene delivery and photothermal therapy.
This does partake in the field of biomedicine, the application of biological and natural science principles into clinical practice (pg 99). …show more content…
Photothermal therapy would support the nano-carriers with the RNA by creating a pathway through the cell to the nucleus. In which the nanomedicine will introduce foreign RNA to modify the genetics while the reactivity of the heat from the P.T therapy would enhance the strength of the nucleotide. There are two methods for this drug delivery. One takes place above 50 degrees Celsius and the other lingers around 45 degrees Celsius. Although the process and materials are the same, the results differ greatly.
The first method of using heat higher than 50 degrees Celsius allows for a strong photothermal effect on the outer membrane of the cell. It would essentially be a battering ram, destroying the outer wall and allowing the therapeutic genes to slip on through. While the RNA gets to work, the photothermal would create an effect called ablation. Ablation would effectively neutralize the protein that is in the cell, thus rendering them harmless to the siRNA that is at …show more content…
The mild light effect would cause the membrane to accept in the nano-medicine thinking that it was ordinary protein. The one downside to this method is that the siRNA is susceptible to attack and degrading from the lysosomes in the cell but this is where the photothermal nanomaterials come in. It is able to support endosomal escape which would allow a siRNA to escape the captivity of the lysosomes by corrupting its outer protein shell. Thus the siRNA that do escape will be twice as effective because it doesn’t have a lysosome to degrade it and it has the photothermal nanomaterials to enhance and accelerate the release of the
This does partake in the field of biomedicine, the application of biological and natural science principles into clinical practice (pg 99). …show more content…
Photothermal therapy would support the nano-carriers with the RNA by creating a pathway through the cell to the nucleus. In which the nanomedicine will introduce foreign RNA to modify the genetics while the reactivity of the heat from the P.T therapy would enhance the strength of the nucleotide. There are two methods for this drug delivery. One takes place above 50 degrees Celsius and the other lingers around 45 degrees Celsius. Although the process and materials are the same, the results differ greatly.
The first method of using heat higher than 50 degrees Celsius allows for a strong photothermal effect on the outer membrane of the cell. It would essentially be a battering ram, destroying the outer wall and allowing the therapeutic genes to slip on through. While the RNA gets to work, the photothermal would create an effect called ablation. Ablation would effectively neutralize the protein that is in the cell, thus rendering them harmless to the siRNA that is at …show more content…
The mild light effect would cause the membrane to accept in the nano-medicine thinking that it was ordinary protein. The one downside to this method is that the siRNA is susceptible to attack and degrading from the lysosomes in the cell but this is where the photothermal nanomaterials come in. It is able to support endosomal escape which would allow a siRNA to escape the captivity of the lysosomes by corrupting its outer protein shell. Thus the siRNA that do escape will be twice as effective because it doesn’t have a lysosome to degrade it and it has the photothermal nanomaterials to enhance and accelerate the release of the