General Facts:
• Aspirin is an acetyl derivative of salicylic acid. It works by reducing substances in the body that cause pain.
• Its scientific name for Aspirin is Acetylsalicylic Acid.
• Another common name for Aspirin is ASA.
• Its chemical formula is C9H8O4 .
• It has a melting point of 136 degrees Celsius and a boiling point of 140 degrees Celsius.
• It's odorless, colorless and can be white powder.
Historic background:
• The origin of aspirin has evolved for the past centuries going from a tree to a tablet. In the early ancient Egyptians time, bark from a willow tree was considered a pain reliever.
• Greek physician, Hippocrates used a bitter powder obtained from willow bark to ease headaches and pains and to reduce fever. …show more content…
• 1969 : A box of Aspirin flies to the moon aboard Apollo 11.
• 2014 : New Aspirin is introduced in which the active ingredient is acetylsalicylic acid. It's used in the form of micro particles, combined with sodium carbonate. This helps New Aspirin dissolve more quickly, enter the bloodstream faster and relieve pain twice as fast as previous Aspirin tablets.
Laboratory Preparation:
• The synthesis of aspirin in labs is very similar to the way of its manufacturing in industry.
• It's considered an esterification reaction where salicylic acid, acting as alcohol, reacts with acetic anhydride, acting as the acid, to produce an ester, acetylsalicylic acid (aspirin), and acetic acid as a by-product.
• Concentrated sulfuric acid is used as a catalyst in this reaction.
Industrial Manufacturing:
• Raw materials:
To produce hard aspirin tablets, we use inactive ingredients as corn starch, cellulose & water and active ingredients as acetylsalicylic acid to serve as both a binding agent and filler, along with a lubricant. Binding agents helps in holding the tablets together, and fillers give the tablets more mass to produce tablets of significant sizes. Some lubricant is added to keep the mixture from sticking onto the machinery. There are different types of Lubricants such as hydrogenated vegetable oil, stearic acid and …show more content…
It can help prevent heart attacks & strokes, specifically ischemic stroke in appropriate patients. Since acetylsalicylic acid, which is considered the main ingredient in aspirin, works by blocking chemical signals in order to reduce pain, fever and swelling, Aspirin can prevent formation of blood clots.
• Nevertheless, Aspirin has some side effects as: ringing in your ears, confusion, hallucinations, rapid breathing ,upset stomach, heartburn, nausea, excessive bleeding and mild headache.
Market:
1. Worldwide Market:
• Approximately about 35,000 metric tons are produced and consumed annually, enough to make over 100 billion standard aspirin tablets every year.
• In 2011, approximately 40,000 tons of aspirin are produced each year and 10 to 20 billion tablets are taken in the U.S. alone each year for prevention of cardiovascular events.
2. Market in Egypt:
• Bayer Middle East (BME) is represented in Egypt since 1960. Bayer Healthcare in the Middle East is considered one of the first pharmaceutical companies, which was established in Egypt.
• In 2014, Bayer Company in Egypt made a 110 % profit rise to be one of the top ten healthcare companies, which overcame average industry rates according to IMS MAT reports published in
• Aspirin is an acetyl derivative of salicylic acid. It works by reducing substances in the body that cause pain.
• Its scientific name for Aspirin is Acetylsalicylic Acid.
• Another common name for Aspirin is ASA.
• Its chemical formula is C9H8O4 .
• It has a melting point of 136 degrees Celsius and a boiling point of 140 degrees Celsius.
• It's odorless, colorless and can be white powder.
Historic background:
• The origin of aspirin has evolved for the past centuries going from a tree to a tablet. In the early ancient Egyptians time, bark from a willow tree was considered a pain reliever.
• Greek physician, Hippocrates used a bitter powder obtained from willow bark to ease headaches and pains and to reduce fever. …show more content…
• 1969 : A box of Aspirin flies to the moon aboard Apollo 11.
• 2014 : New Aspirin is introduced in which the active ingredient is acetylsalicylic acid. It's used in the form of micro particles, combined with sodium carbonate. This helps New Aspirin dissolve more quickly, enter the bloodstream faster and relieve pain twice as fast as previous Aspirin tablets.
Laboratory Preparation:
• The synthesis of aspirin in labs is very similar to the way of its manufacturing in industry.
• It's considered an esterification reaction where salicylic acid, acting as alcohol, reacts with acetic anhydride, acting as the acid, to produce an ester, acetylsalicylic acid (aspirin), and acetic acid as a by-product.
• Concentrated sulfuric acid is used as a catalyst in this reaction.
Industrial Manufacturing:
• Raw materials:
To produce hard aspirin tablets, we use inactive ingredients as corn starch, cellulose & water and active ingredients as acetylsalicylic acid to serve as both a binding agent and filler, along with a lubricant. Binding agents helps in holding the tablets together, and fillers give the tablets more mass to produce tablets of significant sizes. Some lubricant is added to keep the mixture from sticking onto the machinery. There are different types of Lubricants such as hydrogenated vegetable oil, stearic acid and …show more content…
It can help prevent heart attacks & strokes, specifically ischemic stroke in appropriate patients. Since acetylsalicylic acid, which is considered the main ingredient in aspirin, works by blocking chemical signals in order to reduce pain, fever and swelling, Aspirin can prevent formation of blood clots.
• Nevertheless, Aspirin has some side effects as: ringing in your ears, confusion, hallucinations, rapid breathing ,upset stomach, heartburn, nausea, excessive bleeding and mild headache.
Market:
1. Worldwide Market:
• Approximately about 35,000 metric tons are produced and consumed annually, enough to make over 100 billion standard aspirin tablets every year.
• In 2011, approximately 40,000 tons of aspirin are produced each year and 10 to 20 billion tablets are taken in the U.S. alone each year for prevention of cardiovascular events.
2. Market in Egypt:
• Bayer Middle East (BME) is represented in Egypt since 1960. Bayer Healthcare in the Middle East is considered one of the first pharmaceutical companies, which was established in Egypt.
• In 2014, Bayer Company in Egypt made a 110 % profit rise to be one of the top ten healthcare companies, which overcame average industry rates according to IMS MAT reports published in