Friedel-Crafts Reaction Lab Essay
Feb. 10, 2010
Title: The Friedel-Crafts Alkylation Reaction Synthesis of 1,4-di-t-butyl-2,5-dimethoxybenzene with 1,4-dimethoxybenzene and t-butyl alcohol and sulfuric acid
A Friedel-Crafts reaction is a type of electrophilic aromatic substitution reaction that consists of the introduction of an alkyl group onto the benzene ring, otherwise known as alkylation. The first step of Friedel-Crafts alkylation requires the generation of an intermediate carbocation to act as the electrophile during the aromatic substitution process. This is typically done through a reaction of an alkyl halide with a Lewis acid, but this can also be done by the addition of\ H+ to the …show more content…
In this experiment, 1,4-dimethoxybenzne reacted with two equivalents of t-butyl alcohol to form 1,4-di-t-butyl-2,5-dimethoxybenzene via a Friedel-Crafts alkylation mechanism. The electrophilic intermediate carbocation for the reaction was formed through the treatment of t-butyl alcohol with concentrated sulfuric acid. The percent yield was 31.07%, which is fairly low. This was lower due to the fact that many of the crystals remained stuck in the Pasteur pipet during removal of the solvents, and there may have possibly been crystals lost when removing them from the funnel for weighing, etc. There were multiple opportunities when crystals may have been lost.