Formulation Variables Of Clotrimazole-Loaded Cubic Liquid Crystalline Nannoparticles?

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In our previous report, 21 we investigated the influence of formulation variables of clotrimazole-loaded cubic liquid crystalline nanoparticles. The composition of chitosan tailored cubic nanoparticles was optimized employing central composite design. The findings of Small angle X-ray scattering analysis confirmed the presence of D and P cubic phases in nanoparticles. Most importantly, considerable improvement in mucin binding was observed upon incorporation of chitosan owing to electrostatic interaction between cationic chitosan-tailored cubic nanoparticles and anionic mucin layer of mucosa. The optimal conditions obtained were: fraction of Pluronic F127-8.33% (w/w) and concentration of chitosan- 0.17% (w/w). The optimal chitosan-tailored …show more content…
1 compares the rheology of CNC and CC while Fig. 2 illustrates the rheological behavior of CG and CNG. It can be observed that viscosity of cream formulations was remarkably higher to that of gel preparations. Further, in all cases viscosity decreased gradually as shear rate increased indicating pseudoplastic behavior. However, non linear responses were observed in case of cream dosage forms which might be attributed to structural changes caused by shearing.31 The viscosity of CNG was comparatively higher to that of CG. On the other hand, viscosity of CNC was lesser than …show more content…
The order of maximal adhesive force can be ranked as: CNG>CG>CNC>CC>Commercial cream (Clocip®)>Commercial gel (Leezole®).The increased bioadhesivity of gel formulations over cream formulations could be attributed to the presence of the well known mucoadhesive agent HPMC32, 33 employed as gelling agent. Furthermore, it is quite noticeable that cubic nanoparticles based formulations elicited greater mucoadhesion to mucin gel as compared to that of conventional formulations and commercial preparations. Cubic phases are reported to have plausible bioadhesive properties. Further, tailoring of cubic nanoparticles with chitosan has improved the adhesivity of gel and cream to the mucin possibly by ionic interaction between cationic amino group of chitosan and anionic mucin. 34,

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