Formulae Of Levodopa Floating Tablets

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CHAPTER-V

FORMULATION AND EVALUATION OF LEVODOPA FLOATING TABLETS

FORMULATION AND EVALUATION OF LEVODOPA FLOATING TABLETS

Several approaches are currently used to retain the dosage form in the stomach. The principle of the floating tablets is simple and practically approach to achieve increased gastric residence time to obtain controlled release floating tablets designed based on the gas generating principle needs a strong floating matrix former. In this regard HPMC K4M, HPMC K15M and HPMC K100M were tried as strong controlled release floating matrix formers in the formulation of Levodopa floating tablets.

EXPERIMENTAL
Materials:
1) Levodopa (Richer Pharmaceuticals-Hyderabad).
2) HPMC
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Formulation Hardness (Kg/Cm2) ± S.D Friability
(%) ± S.D Drug Content (mg/tab) ± S.D Floating Lag Time (m) ± S.D(s) Floating
Time (h) ± S.D
F1 5.1 ± 0.01 0.19 ± 0.011 98.34± 0.12 04 ± 11 6 ± 0.011
F2 5.5 ± 0.02 0.23 ± 0.012 98.54 ± 0.47 05 ± 10 7 ± 0.021
F3 5.1 ± 0.04 0.41 ± 0.015 99.21 ± 0.08 06 ± 20 10 ± 0.052
F4 5.1 ± 0.41 0.21 ± 0.014 99.19 ± 0.45 07 ± 09 5± 0.451
F5 5.2 ± 0.33 0.28 ± 0.018 98.92 ± 0.23 04 ± 40 06 ± 0.014
F6 5.3 ± 0.32 0.12 ± 0.018 97.42 ± 0.69 02± 03 11 ± 0.051
F7
F8
F9 5.1 ± 0.3
5.5 ± 0.46
5.3 ± 0.22 0.26 ± 0.010
0.15 ±
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Fig.5.13: Square Root Time Vs Percent Released Plots of Levodopa Floating Tablets (F1-F3)

Fig.5.14: Square Root Time Vs Percent Released Plots of Levodopa Floating Tablets
(F4-F6)

Fig.5.15: Square Root Time Vs Percent Released Plots of Levodopa Floating Tablets
(F7-F9)

Fig.5.16: Square Root Time Vs Percent Released Plots of Levodopa Floating Tablets
(F1,F4,F7)

Fig.5.17: Square Root Time Vs Percent Released Plots of Levodopa Floating Tablets
(F2,F5,F8)

Fig.5.18: Square Root Time Vs Percent Released Plots of Levodopa Floating Tablets
(F3,F6,F9)

Fig.5.19: Log time Vs Log Percent Released Plots of Levodopa Floating Tablets (F1-F3)

Fig.5.20: Log time Vs Log Percent Released Plots of Levodopa Floating Tablets (F4-F6)

Fig.5.21: Log time Vs Log Percent Released Plots of Levodopa Floating Tablets (F7-F9)

Fig.5.22: Log time Vs Log Percent Released Plots of Levodopa Floating Tablets (F1,F4,F7)

Fig.5.23: Log time Vs Log Percent Released Plots of Levodopa Floating Tablets

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