The film takes place in town Upper Darby, Rhode Island. In 1990, medics diagnose Sara's daughter, Kate, with a aggressive form of leukemia. Doctors said Kate might die and that news shocks Sara and her firefighter husband. Sara immediately resolves to commence Kate on treatment. Kate commences chemotherapy and her oncologist, Dr. Chance suggest that she might eventually need a bone marrow transplant and preferably from a cognate donor. Dr. Chance mentions that another unborn siblings could be match because their four year old son, Jesse not a match for donor. Sara suggests to Brian that they need have another child. Kate goes into renal failure when she turns 15. Anna, eleven years old knows that she have to donate one of her kidneys and will
