Fentanyl Analysis

Fentanyl can be administrated through transdermal route. Drugs must across many layers of epidermis and dermis before getting into bloodstream, so the absorption rate of Fentanyl is low. However, the bioavailability of Fentanyl by transdermal route is quiet high(80-100%) because no Fentanyl is metabolised by liver before absorption. Fentanyl can also be administred by sublingual route and buccal route. By sublingual route, the rate of absorption is also high because there are many capillaries under the tongue. By buccal route, there are many capillaries in buccal cavity. Fentanyl can enter the blood rapidly through capillaries by sublingual route and buccal route. The bioavailability of drugs by buccal and sublingual routes are high because drugs can enter bloodstream without passing through liver. The most efficient route is intravenous injection. By the injection, Fentanyl can be introduced into the veins directly across all body’s barrier defenses, so the rate of absorption is the highest. In addition, bioavailavility of Fentanyl by intravenous injection is 100%. Most of the drugs can be absorbed rapidly. …show more content…
Children usually contain less body fat, so less drugs can dissovle into adipose tissue. As a result, the drug concentration in the bloodstream of children is higher than that in the adults even with the same dosage. More drugs distribute to the tissues in children, so the dosage of children should be lower to prevent overdose. In this case, Prince applied a high dosage of Fentanyl, but his fat tissues are too little for Fentanyl to dissolve into it. Hiigh concentration of Fentanyl stays in the bloodstream and enters body tissues. This results in Fentanyl