Asthma and chronic obstructive pulmonary disease (COPD) are among the most common and prevalent diseases in the world (Raadhika and Shanthi, 2012; Rao and Kulkarni , 2012). Salbutamol sulphate (SS) is a short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm (Sharma et al., 2015). Salbutamol sulphate is readily absorbed from the gastro intestinal tract following oral administration, and it undergoes the first pass metabolism in the liver. It requires multiple dosing a day because its oral bioavailability is just about 50% and its plasma half-life is 4 to 6 h. (Prasanth et al., 2014). Salbutamol sulphate is usually given by slow intravenous injections (painful administration) in the management of severe asthmatic attacks (Srinivas et al., 2011) or inhalation using metered dose inhalers (MDIs), nebulisers or other proprietary
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The surface pH of the prepared films was measured by bringing electrode in contact with film surface and allowed to equilibrate using a pH meter (Jenway 3310, UK). The test was done in triplicate and the results expressed as mean ± SD. (Satyanarayana and Keshavarao , 2012)
Mechanical characteristics
The tensile properties test was performed by using a Chacillon force measurement apparatus (Greenspora, NC27409, Mumbai, India) in which the tensile strength, percent elongation and elastic modulus were measured. The apparatus has two clamps the upper is fixed and the lower is movable. The film sample (1x3 cm) was clamped between the two clamps. The test was done in triplicate for each film formula (EL-Setouhy and Abd El-Malak, 2010). The tensile strength, percent elongation (%E) and elastic modulus were determined using the following equations:
Tensile strength = Load at failure × 100/Strip thickness × Strip width (1)
% E = [(Ls- L0)/L0] x l00 (2)
Where L0 is the original length and Ls is the length of the film after
The surface pH of the prepared films was measured by bringing electrode in contact with film surface and allowed to equilibrate using a pH meter (Jenway 3310, UK). The test was done in triplicate and the results expressed as mean ± SD. (Satyanarayana and Keshavarao , 2012)
Mechanical characteristics
The tensile properties test was performed by using a Chacillon force measurement apparatus (Greenspora, NC27409, Mumbai, India) in which the tensile strength, percent elongation and elastic modulus were measured. The apparatus has two clamps the upper is fixed and the lower is movable. The film sample (1x3 cm) was clamped between the two clamps. The test was done in triplicate for each film formula (EL-Setouhy and Abd El-Malak, 2010). The tensile strength, percent elongation (%E) and elastic modulus were determined using the following equations:
Tensile strength = Load at failure × 100/Strip thickness × Strip width (1)
% E = [(Ls- L0)/L0] x l00 (2)
Where L0 is the original length and Ls is the length of the film after