Experiment 1 Px rats were randomly divided into six groups. Four groups were assigned into OVX, whereas two groups were formed for the sham operation (Sham). The OVX rats were assigned into the following four groups: 1) estrogen replacement _ exercise (OVX-ER-EX), 2) estrogen replacement (OVX-ER), 3) exercise (OVX-EX), and 4) placebo (saline; OVX). The Sham rats were assigned into the following two groups: 1) exercise (Sham-EX) and 2) placebo (Sham). All rats freely consumed a 30% fat diet for 8 wk. Rats in the estrogen replacement groups were ip administered daily with 30 _g 17_-estradiol/kg bw. Rats in the exercise groups ran on an uphill treadmill at 20 m/min for 30 min four times a week.
Experiment 2 Px rats were divided into four groups:
Experiment 2 Px rats were divided into four groups: