It has been already stated that the definite causes of essential hypertension (which accounts for 95% of conditions) are not known, but it is associated with a number of factors that might increase that patients probability of developing hypertension like, age, obesity, insulin resistance (diabetes), high alcohol intake, high salt intake (especially in salt-sensitive patients), and sometimes sedentary life style, stress, low potassium and calcium intake can cause hypertension, also, high blood pressure can be caused by variation in the genes controlling blood pressure, so genes and family history play a major role in hypertension.[1][2]
On the other hand, secondary hypertension )which accounts for 5% of the conditions) has a definite cause, …show more content…
The major underlying mechanism for endothelial dysfunction seen in HTN is the decrease in the availability of nitric oxide (NO) which function is vasorelaxation, a consequence of increased oxidative stress in these patients.[1][3][4]
Vasoactive substances:
Endothelin, a potent vasoconstrictor is one of the major substances involved in maintaining vascular tone, it is secreted by endothelial cells and exerts its affects in a paracrine or autocrine manner on vascular smooth muscle cells and counteracts the relaxing activity of
On the other hand, secondary hypertension )which accounts for 5% of the conditions) has a definite cause, …show more content…
The major underlying mechanism for endothelial dysfunction seen in HTN is the decrease in the availability of nitric oxide (NO) which function is vasorelaxation, a consequence of increased oxidative stress in these patients.[1][3][4]
Vasoactive substances:
Endothelin, a potent vasoconstrictor is one of the major substances involved in maintaining vascular tone, it is secreted by endothelial cells and exerts its affects in a paracrine or autocrine manner on vascular smooth muscle cells and counteracts the relaxing activity of