Essay On Tumor Microenvironments

Tumor microenvironments consist of solid tumors and a matrix of blood supply. This also consist of a variety of immune cells that aid in cell signaling. This environment functions off the recruitment of chemoattractants, growth hormones, cytokines, and other key elements. Myeloid derived stem cells play a major role in tumor microenvironments. The stems cells that come stem from here are stimulated with various factors. Myeloid progenitor stem cells stimulated with erythropoietin gives rise to red blood cells. Stimulation with interleukin 5 gives rise to eosinophils, stimulation with thrombopoeiten gives rise to megakaryocytes which gives rise to platelets. The others are basophils, neutrophils, monocytes, and dendritic cells. Each of these …show more content…
A branch of stem cells derived from myeloid stem cells are neutrophils. Neutrophils are circulating, phagocytic granulocytes that are the first line of defense in the immune response. The neutrophils make up 40-80% of white blood cells. They are said to aid in metastasis and growth within the tumor microenvironment, however many researchers are still studying their role. Studies have shown they increase the breakdown of extracellular matrix and strengthen the ability of environment to provide a distinguished blood supply. Additionally other studies have found that neutrophils accelerate the growth of the tumors. Also in this same group are macrophages. Macrophages are monocytes in tissue that arise from granulocyte monocyte progenitor cells. They are mononeuclear phagocytic leukocytes that