Essay On Resveratrol

. SIRT1 is one of the many vital genes that is highly controlled during caloric restriction, which leads to a number of biological variations to extend lifespan. Resveratrol’s activation of the SIRT1 gene affects a number of cellular processes. Resveratrol decreases nuclear factor kappa B (NFκB) activation.The nuclear factor kappa B is located in the cellular cytoplasm and moves to the nucleus upon activation where it stimulates transcription of multiple pro- inflammatory genes such as TNFα, IL-1, and IL-8. Resveratrol’s has a blocking action of NFκB that also inhibits iNOS, COX-1 and COX-2 expression (these are factors responsible for inflammation which is a prevailing side-effect for most pills) as well as many other genes including multiple cell adhesion molecules.Thus, resveratrol’s …show more content…
This process allows higher metabolic energy to be produced through oxidative phosphorylation and decreases oxidative stress on the muscle cells. This has been revealed based on observation through rodent studies whereby resveratrol supplementation significantly increased treadmill running times. The end result is improved exercise endurance performance. Resveratrol itself has antioxidant properties and upregulates cellular mechanisms of oxidative resistance by inducing mitochondrial superoxide dismutase in human cells. The cardioprotective effects of resveratrol and other polyphenols may be in part to their ability to decrease LDL cholesterol oxidation, and therefore the pro-inflammatory cascade that ultimately leads to atherosclerotic plaque formation. This has been demonstrated using grape juice in animal and human models.There are a variety of other mechanisms by which resveratrol may provide cardioprotective effects at various plasma concentrations reviewed .These include mechanisms of increasing endothelial nitric oxide synthase (eNOS) expression in endothelial cells, suppression of platelet activity, activation of adenosine receptors, and