Over the last decades, resveratrol has steadily gained increased attention in relation to metabolic health.29 Although there has been a substantial number of clinical trials investigating the metabolic effects induced by resveratrol in the general population, this is the first study evaluating the differences in OS, antioxidants and CRP parameters among individuals with SZ. In the present double-blind, placebo-controlled study, no significant resveratrol-induced changes were found in TBARS, GPx and CRP levels.
There is a clear association between low-grade inflammation and obesity-associated diseases. Thus, the development of new anti-inflammatory substances is needed and resveratrol is a candidate molecule.29 Unfortunately, our study did not show significant anti-inflammatory effects after resveratrol supplementation. Rather, we observed that there was a slight decreasing trend in CRP in the resveratrol group after the 4-week supplementation while we observed an increasing trend in the placebo group. In addition, TBARS clearly showed an increasing trend in the placebo group and a decreasing trend in the resveratrol group, which seems to suggest that resveratrol tends to offer benefits to prevent OS and lipid peroxidation. This represents a relevant clinical finding as …show more content…
Given the thousands of publications investigating resveratrol in laboratory models, it is rather surprising that so few studies have evaluated the efficacy of resveratrol in humans.23 A few human studies have confirmed the antioxidant and anti-inflammatory effects of resveratrol previously found in experimental or animal studies.31 These effects are mostly tiny and the results are sometimes controversial as they depend on the protocols used (ie dose, form of administration, patients’ characteristics, adjuvant therapy).34,35 Moreover, individual values often vary substantially from subject to subject and results between studies are difficult to compare because of the different protocols
There is a clear association between low-grade inflammation and obesity-associated diseases. Thus, the development of new anti-inflammatory substances is needed and resveratrol is a candidate molecule.29 Unfortunately, our study did not show significant anti-inflammatory effects after resveratrol supplementation. Rather, we observed that there was a slight decreasing trend in CRP in the resveratrol group after the 4-week supplementation while we observed an increasing trend in the placebo group. In addition, TBARS clearly showed an increasing trend in the placebo group and a decreasing trend in the resveratrol group, which seems to suggest that resveratrol tends to offer benefits to prevent OS and lipid peroxidation. This represents a relevant clinical finding as …show more content…
Given the thousands of publications investigating resveratrol in laboratory models, it is rather surprising that so few studies have evaluated the efficacy of resveratrol in humans.23 A few human studies have confirmed the antioxidant and anti-inflammatory effects of resveratrol previously found in experimental or animal studies.31 These effects are mostly tiny and the results are sometimes controversial as they depend on the protocols used (ie dose, form of administration, patients’ characteristics, adjuvant therapy).34,35 Moreover, individual values often vary substantially from subject to subject and results between studies are difficult to compare because of the different protocols