Betahistine - Dose and Duration Dependent Effect
Effectiveness of betahistine has been demonstrated to be dose-and time-dependent. Reportedly, 48 mg daily during 3 months seems to be the most successful therapeutic scheme for MD and other types of peripheral vertigo. This dosage has been shown to be useful in controlling symptoms, reducing frequency and intensity of attacks, facilitating vestibular compensation, improving quality-of-life and preventing new episodes1. Additionally, an experimental study has shown that betahistine produced a dose-dependent inhibition of induced spike generation of polysynaptic neurons in lateral vestibular nucleus 8.
Appropriate dosage and duration of treatment are the key components of Betahistine therapy success1
Betahistine - Ideal Dose
The most interesting aspect of betahistine is its dose-dependent effect which is reported in several clinical studies4. Initial treatment with betahistine in adults is usually in the range of 8–16 mg 3-times daily, and maintenance doses normally in the range of 24–48 mg daily. Dosage can be adjusted according to response to treatment. Improvement could be observed after a couple of weeks of treatment, but usually better results are observed after 1–6 …show more content…
A total of 305 patients with vestibular vertigo completed that study. The result of the study reported that betahistine (48 mg/day) was found to be effective for the treatment of vestibular vertigo. Betahistine treatment for up to 60 days was associated with significant reductions in vertigo severity (p < 0.001), as assessed by changes in SVVSLCRE level. Importantly, improvement continued beyond day 30 of treatment, highlighting that clinicians may want to consider duration of betahistine treatment when trying to achieve maximal potential
Effectiveness of betahistine has been demonstrated to be dose-and time-dependent. Reportedly, 48 mg daily during 3 months seems to be the most successful therapeutic scheme for MD and other types of peripheral vertigo. This dosage has been shown to be useful in controlling symptoms, reducing frequency and intensity of attacks, facilitating vestibular compensation, improving quality-of-life and preventing new episodes1. Additionally, an experimental study has shown that betahistine produced a dose-dependent inhibition of induced spike generation of polysynaptic neurons in lateral vestibular nucleus 8.
Appropriate dosage and duration of treatment are the key components of Betahistine therapy success1
Betahistine - Ideal Dose
The most interesting aspect of betahistine is its dose-dependent effect which is reported in several clinical studies4. Initial treatment with betahistine in adults is usually in the range of 8–16 mg 3-times daily, and maintenance doses normally in the range of 24–48 mg daily. Dosage can be adjusted according to response to treatment. Improvement could be observed after a couple of weeks of treatment, but usually better results are observed after 1–6 …show more content…
A total of 305 patients with vestibular vertigo completed that study. The result of the study reported that betahistine (48 mg/day) was found to be effective for the treatment of vestibular vertigo. Betahistine treatment for up to 60 days was associated with significant reductions in vertigo severity (p < 0.001), as assessed by changes in SVVSLCRE level. Importantly, improvement continued beyond day 30 of treatment, highlighting that clinicians may want to consider duration of betahistine treatment when trying to achieve maximal potential