Introduction:
Epilepsy is one of the most common neurological disorders observed approximately in 1-3% of population, it has affected around 70 million people worldwide and nearly 90% of them are found in developing regions (Ngugi et al; 2010). The corresponding figure for India was estimated to be more than 12 million with 1% prevalence contributes nearly one-sixth of the global burden (Senthil Amudhan et al., 2015). Epilepsy is a brain disorder characterized by an enduring predisposition to generate seizures and by its neurobiological, cognitive, psychological, and social consequences (Nandanavana et al., 2014). It?s a condition characterized by recurrent (two or more) epileptic seizures, unprovoked by any immediate identified cause (Hauser et al., 1975). An epileptic seizure is a clinical …show more content…
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stressactivated signaling pathway and apoptotic pathways. Prog Neurobiol2003;69:103?42.
Georgi Maximov, Konstantin Maximov , Yulia Maximova. Molecular Factors of Seizures ? Induced Neuronal Cell Death in Epilepsy and Potential Possibility for Neuroprotective Therapy. Pharmacology. 2009; 3: 411-416.
David C. Henshall, Tomohiro Araki, Clara K. Schindler, Jing-Quan Lan, Kenneth L. Tiekoter, Waro Taki, and Roger P. Simon. Activation of Bcl-2-Associated Death Protein and CounterResponse of Akt within Cell Populations during Seizure-Induced Neuronal Death. The Journal of Neuroscience. 2002;22(19):8458?8465.
Komaki S, Kohno M, Matsuura N, Shimadzu M, Adachi N, Hoshide R, Nishiyama S, Matsuda I. The polymorphic 43Thr BCL-2 protein confers relative resistance to autoimmunity: an analytical evaluation. Hum Genet 1998; 103:435?440.
Matthew J. Betts and Robert B. Russell. Amino Acid Properties and Consequences of Substitutions. Chapter 14. Bioinformatics for Geneticists. Edited by Michael R. Barnes and Ian C. Gray. 2003; 289-
Epilepsy is one of the most common neurological disorders observed approximately in 1-3% of population, it has affected around 70 million people worldwide and nearly 90% of them are found in developing regions (Ngugi et al; 2010). The corresponding figure for India was estimated to be more than 12 million with 1% prevalence contributes nearly one-sixth of the global burden (Senthil Amudhan et al., 2015). Epilepsy is a brain disorder characterized by an enduring predisposition to generate seizures and by its neurobiological, cognitive, psychological, and social consequences (Nandanavana et al., 2014). It?s a condition characterized by recurrent (two or more) epileptic seizures, unprovoked by any immediate identified cause (Hauser et al., 1975). An epileptic seizure is a clinical …show more content…
To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stressactivated signaling pathway and apoptotic pathways. Prog Neurobiol2003;69:103?42.
Georgi Maximov, Konstantin Maximov , Yulia Maximova. Molecular Factors of Seizures ? Induced Neuronal Cell Death in Epilepsy and Potential Possibility for Neuroprotective Therapy. Pharmacology. 2009; 3: 411-416.
David C. Henshall, Tomohiro Araki, Clara K. Schindler, Jing-Quan Lan, Kenneth L. Tiekoter, Waro Taki, and Roger P. Simon. Activation of Bcl-2-Associated Death Protein and CounterResponse of Akt within Cell Populations during Seizure-Induced Neuronal Death. The Journal of Neuroscience. 2002;22(19):8458?8465.
Komaki S, Kohno M, Matsuura N, Shimadzu M, Adachi N, Hoshide R, Nishiyama S, Matsuda I. The polymorphic 43Thr BCL-2 protein confers relative resistance to autoimmunity: an analytical evaluation. Hum Genet 1998; 103:435?440.
Matthew J. Betts and Robert B. Russell. Amino Acid Properties and Consequences of Substitutions. Chapter 14. Bioinformatics for Geneticists. Edited by Michael R. Barnes and Ian C. Gray. 2003; 289-