Enzymology, Catalytic Mechanism, Carbohydrate Metabolism, Adenosine Triphosphate

1986 Words Oct 21st, 2012 8 Pages
Enzymology, Catalytic Mechanism, Carbohydrate Metabolism, Adenosine Triphosphate
Enzymes are proteins and their function is to act as catalysts to speed up certain chemical reactions in the cell that would be slower without them. This process occurs as steps in a cycle with separate reactions in each step. If there is a missing product the step in the cycle will be incomplete and the normal function of the organism cannot be accomplished causing negative effects on the organism. The biological processed of the body would occur much more slowly or possibly not at all without the presents of enzyme reactions.
Enzymes have some very specific qualities. Enzymes are sensitive to temperature and they tend to work faster as temperature
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Aldolase B is the only enzyme able to breakdown F1P and therefore keeps it from becoming toxic causing cell death. Adolase B catalyzes F1P through hydrolysis to form glyceraldehyde and dihydroxyacetone phosphate (DHAP). This breakdown forming these two molecules allows fructose to enter glycolysis from an indirect pathway in order to continue to breakdown the molecules to form either more energy through ATP production or to release more stored sugar from the liver to prevent hypoglycemia depending on the needs of the body at that time (GHR, 2011). Adolase B is crucial in the breakdown of fructose, without this enzyme the body would not be able to process or use this sugar.
An important role of aldolase B is in the metabolism of fructose. This mainly happens in the liver, but also occurs in the small intestine and renal cortex. After fructose is phosphorylated (adding a phosphate group) by fructokinase to form F-1-P, it is then catalyzed by aldolase B to form glyceraldehyde and DHAP. Glyceraldehyde is phosphorylated by the enzyme triose kinase to form glyceraldehyde 3-phosphate (GP3) and DHAP is converted into GP3 by triose phosphate isomerase where the newly converted molecules enter glycolysis and are now on a direct pathway to be fully broken down

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