Ellen Heber-Katz, Ph.D. began her research in 1996 while doing an experiment, coming across a phenomenon in a mammal accidentally. She had been using mice from the MRL (Also known as Murphy Roths Large) strain, which have been used for almost 40 years in immunology research, due to them showing autoimmune disorders later in their life, because it is easy to use these mice in studies of comparable defects and diseases and they are also very docile, in an autoimmunity experiment. It is common in experiments involving mice to punch holes in their ears to identify them throughout their entire lives, or at least within an experiment being completed. However, when Heber-Katz and other researchers looked at the mice a few weeks later, they noticed
