Effects Of Sreptomycin For Tuberculosis

794 Words 4 Pages
Harinder Mootoor
Dr. Koria
Term Paper 1
Streptomycin for Tuberculosis
Diseases are very detrimental to the health and lives of humans. Many diseases are caused by the spread of harmful bacteria. One specific disease that has a large effect on the population is tuberculosis (TB). Tuberculosis is caused by the spread of a bacterium and if the bacterium is not treated properly, TB can be fatal. With the use of antibiotics, such as streptomycin, the fundamental process of DNA replication, transcription, and translation can be altered to the advantage of curing TB.
Tuberculosis is an infectious disease that is spread via the air. According to the World Health Organization, tuberculosis is estimated to kill 1.5 million
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Streptomycin is a common example of an antibiotic that aids in the cure of TB. Streptomycin acts as a protein synthesis inhibitor. It works by causing the translation process to make more mistakes than usual. Usually, in the DNA replication, transcription, and translation process, there is less than one error for every billion, or more, base pairs copied (McCulloch). With the use of streptomycin, as high as one mistake for every 100 amino acids occur. Proteins with this many errors are not capable of performing their tasks, and the cells (in this case, bacteria) die. Streptomycin also inhibits the initiation of the synthesis process, causing the spread of bacteria to decrease immensely (Holme). Because humans have ribosomes, which are structurally different in comparison to bacteria, this drug does not have any effect on human cells …show more content…
In the disease, tuberculosis, the mycobacterium tuberculosis is the bacterium that causes the harmful effects in tuberculosis. The bacterium spreads throughout the body through methods similar to protein synthesis. However, certain antibiotics such as, streptomycin, help prevent and cure cases of TB. The antibiotics work through altering or interfering in the processes of replication, transcription, and translation. Streptomycin is a specific anti-biotic that helps inhibit the protein synthesis of the bacterium, essentially declining the rate of growth and killing off the rest of the bacterium. I believe this is a wonderful advancement in technology and a clever piece of innovation. Using the basic principles of DNA replication, transcription, and translation, harmful bacteria can spread quickly. Yet, using the same principles of DNA replication, transcription and translation, prevention methods and cures can be found by manipulating these processes to our

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