By
Billy John Muro
For
Mr. Jose Maldonado
Biol 1307
December 6, 2016
Abstract
America Trypanosomiasis most commonly known as Chagas disease (ChD) is caused by a protozoan parasite known as Trypanosoma cruzi. This disease affects 7 to 8 million people worldwide. Current treatments such as benznidazole and nifurtimox are partially effective and cause severe side effects, for this reason there is an urgent need to improve the chemotherapeutic treatment against ChD. Consequently, research must be conducted to investigate the anti-parasitic activity of experimental compounds in T. cruzi. In vitro techniques are the first step in a ladder for experimental compounds …show more content…
media coverage to inform the public about this disease is lacking, therefore it is up to Researchers and laboratories to find treatments to inhibit the parasite Trypanosoma cruzi that is involved in Chagas disease.
I. Introduction of Chagas Disease
A. Trypanosoma cruzi and Chagas disease
1. History and who discovered it.
2. What causes Chagas disease?
B. How is the Disease transmitted
1. Life Cycle
2. Who is impacted by this Disease (Epidemiology)
II. Treatments
A. Current treatments and side …show more content…
Carlos Chagas was who first described the parasite Trypanosoma cruzi in infected humans in 1909 while employed under Oswaldo Cruz at an Institute in Brazil. Chagas discovered that the parasites T. cruzi are transmitted to humans by introducing themselves in breaks in the skin such as cut or the bite wound of a Triatominae bug, after they are deposited on the skin. Chagas was the first scientist to discover all aspects of a new infectious disease: its pathogen (T. cruzi), main insect vector (Triatominae commonly known as kissing bugs), hosts (humans, mammals), clinical manifestations, and epidemiology. The parasite species was named cruzi to honor his employer and scientific mentor, Oswaldo Cruz.”(PHD