Dupilumab Case Studies

Improved Essays
If you have eczema--especially if you haven't found an effective treatment for your unbearably itchy skin--you may want to schedule an appointment with your dermatologist soon. For the first time in decades, there is a promising new treatment for eczema on the horizon. Dupilumab is being heralded as a breakthrough medication, and stock prices for Regeneron Pharmaceuticals, its developer, are climbing fast. The research is very promising, and physicians are hopeful that they can begin to offer the new medicine to eczema sufferers as soon as 2017. But is this new treatment all it promises to be? Will dupilumab be the cure for eczema?

What is dupilumab?

Dupilumab is a treatment in a new medicine class called biologics. It treats inflamed skin systemically, rather than topically. Dupilumab is given as a shot every other week to calm the immune system. It targets specific signaling pathways of the immune system that researchers believe cause the inflamed skin of eczema.
…show more content…
Dupilumab has gone through several clinical trials to test its effectiveness and has demonstrated convincing results at each phase. In its most recent testing, Phase 3, researchers selected 1,379 subjects with moderate-to-severe atopic dermatitis and randomly assigned them to receive dupilumab or a placebo. Those who were given dupilumab showed significant symptom improvement compared to those who were given the placebo.

When will dupilumab come on the U.S.

Related Documents

  • Improved Essays

    Oseltamivir: A Case Study

    • 632 Words
    • 3 Pages

    Oseltamivir is an antiviral drug used in the treatment and prophylaxis of both influenza virus A and influenza virus B. It was approved for seasonal influenza by US Food and Drug Administration in 1999, and approval from Japanese agencies and European Medicines Agency (EMA) followed soon afterwards. A pharmaceutical company Roche launched oseltamivir in the global market with Tamiflu as its brand name. In 2007 alone this pharmaceutical company was producing 400 million doses of the drug with a market value of 2.2 billion US dollars, and benefitted by more than 18 billion US dollars since the launch of the drug.…

    • 632 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Activity 15.1 Essay

    • 904 Words
    • 4 Pages

    3. Peter Robinson, M.D., has discovered an effective inexpensive cure for eczema acne and psoriasis. 4. In the shower by the drain you can see the crack starting to develop.…

    • 904 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Neutropenia Case Study

    • 898 Words
    • 4 Pages

    Even with the neupogen shots that we had to inject into her three times per week, her numbers never came up. I am convinced that with the proper Neutropenia treatment, her eczema allergies and asthma will be healed by the blood of JESUS! The Method If we look at the chain of events, we see that none of the other health problems occurred before she entered the swimming pool. One theory is that the pool was not cleaned properly, therefor infecting future swimmers. The doctors kept asking the same questions but it didn 't dawn on me to until a few months later.…

    • 898 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Rituximab Research Paper

    • 347 Words
    • 2 Pages

    Rituximab, a chimeric human and murine monoclonal antibody, targets the CD20 antigen expressed on pre-B cells and mature B-lymphocytes [55]. The antibody was originally developed for the treatment of B-cell lymphoma [56]. Recently, it has been administered for treating different autoimmune disease. As rituximab is an IgG1 subclass antibody, it crosses the placenta, interfering with fetal and neonatal B cell development and could lead to immune deficiency and raise susceptibility to infections in the neonate [57].…

    • 347 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    Natalizumab Case Study

    • 788 Words
    • 4 Pages

    T cells also have effect on Natalizumab in patients with multiple sclerosis. Natalizumab is a monoclonal antibody that reduces the formation of acute lesions in the central nervous system. Bornsen et. al revealed the influence that natalizumab has on circulating CD4+ T cells in multiple sclerosis. The recurrence of multiple sclerosis happens when there are abnormalities in activated macrophages, CD4+ and CD8+ T cells in the central nervous system.…

    • 788 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    Nivolumab Case Studies

    • 949 Words
    • 4 Pages

    However, the specificity of pidilizumab for PD-1 has been questioned and investigations are exploring this issue, hence it is still in early stage development of targeting PD-1 receptors (Festino et al.…

    • 949 Words
    • 4 Pages
    Improved Essays
  • Decent Essays

    Adalimumab Research Paper

    • 209 Words
    • 1 Pages

    Adalimumab is a monoclonal antibody, so it is highly specific. As mentioned above, it specifically binds to TNF alpha (tumor necrosis factor alpha). TNF alpha is a signaling protein, a cytokine, which is involved in the normal inflammatory response as part of the immune system. For people who suffer from Rheumatoid Arthritis for example, there is an increased level of TNF alpha in the synovial fluid between the joints. This is harmful because it causes excess inflammation and pain ultimately causing destruction of the joint.…

    • 209 Words
    • 1 Pages
    Decent Essays
  • Improved Essays

    Lupus Research Paper

    • 1129 Words
    • 5 Pages

    Abstract Lupus is a chronic autoimmune disease in which the human immune system is overactive. Chronic means that the signs and symptoms tend to last longer than six weeks and can last up to several years (Lupus Foundation of America, 2014). Autoimmune means the immune system cannot tell the difference between foreign invaders and healthy tissues within the body. Therefore, the body attacks itself by creating auto-antibodies that destroy the remaining healthy tissue (Lupus Foundation of America, 2014).…

    • 1129 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    Lupus Research Paper

    • 1477 Words
    • 6 Pages

    Lupus is short for a known condition called Systemic Lupus Erythematosus (SLE). Lupus is an autoimmune disease, which means the body, attacks its own cells. It affects different organs including the skin, joints, heart, lungs, blood, kidneys, and the brain. At least 5 million people worldwide have a form of lupus but more than 90% of the patients diagnosed with this particular deadly disease are women. People that usually develop this disease are young teens and middle-aged adults.…

    • 1477 Words
    • 6 Pages
    Improved Essays
  • Improved Essays

    Lupus. Most of you are thinking “What the heck is this guy talking about?” Am I right? Well for those of you who do not know what Lupus is, I’m here to explain. Lupus is a chronic, autoimmune disease that can damage any part of the body including skin, joints, and/or organs inside the body.…

    • 503 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Eczema Research Paper

    • 535 Words
    • 3 Pages

    If you have been newly diagnosed with eczema, then you may not know where to begin when reevaluating your current skincare routine. If your dermatologist has prescribed an eczema medication for you to use daily or only during bad flares, then that is the most important item to include in your skincare routine, but doesn't have to be the only one. Look for these three ingredients that help keep your skin calm to prevent flares and can also stop a mild flare in its tracks, before it worsens. Colloidal Oatmeal Colloidal oatmeal is just a fancy name for very finely milled oats, and you can find it in premade skincare products or as a single ingredient. When it is present in skincare products, typically lotions and creams, you can simply apply it to the areas where you commonly develop flares every day to keep the skin calm.…

    • 535 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    Lupus Research Papers

    • 686 Words
    • 3 Pages

    Lupus is a chronic, complex and prevalent autoimmune disease that affects more than 1.5 million Americans. (LRI) Many youth have contracted this disease, Lupus can affect your brain, organs, bones, tissues, etc. The body begins to fight it self killing healthy body cells thinking they are malicious. The lupus research institute helps fund beginning operations for finding a cure for lupus.…

    • 686 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    My parents tried and failed to seek the medicine that would even lessen the suffering or annoyance of this disease. We searched from Texas to Wuhan in China, trying different lotions, pills, special baths, but none of these supposed solutions provided any permanent aid but rather an occasional reduction of the itchiness. So I stuck with a lotion called Cetaphil which helped with my irritated skin, but provided only minor relief. I saw this irritation as something unfair. It provided excuses, anger, and reasons to fail.…

    • 2354 Words
    • 10 Pages
    Improved Essays
  • Improved Essays

    Lupus Case Studies

    • 1390 Words
    • 6 Pages

    Introduction Lupus is an autoimmune disease that occurs when an individual’s immune system attacks his or her own tissues and organs. Lupus varies significantly from individual to individual and can affect a variety of body systems, such as an individual’s kidneys, blood cells, skin, brain, heart, and lungs (Mayo Clinic, 2017). In the United States, an estimated 1.5 million individuals are living with lupus, and there are a reported 16,000 new cases of lupus each year (Lupus Foundation of America, 2013) While lupus has an unknown etiology, it is theorized that lupus occurs due to a combination of an individual’s genetics and various environmental factors, such as sunlight, infections, or medications (Mayo Clinic, 2017). Furthermore, there…

    • 1390 Words
    • 6 Pages
    Improved Essays
  • Improved Essays

    Get Rid Of Eczema Essay

    • 573 Words
    • 3 Pages

    What is eczema ? Before we jump into the causes, just what exactly is eczema? " Eczema is a term for various types of skin inflammation (dermatitis). The symptoms of eczema commonly include itching, redness and dry skin. "…

    • 573 Words
    • 3 Pages
    Improved Essays