Drug Class : Central Nervous Stimulants Essay

1615 Words Sep 3rd, 2015 7 Pages
Names: Generic: modafinil, Trade name in New Zealand: MODAVIGIL® (MIMS 2015).
Drug class: Central nervous stimulants (Wake- promoting agents) (Ballon and Feifel, 2006)
Formulation: Modavigil ® is formulated as modafinil white to off-white, crystalline powder in tablet form. It is available in tablets containing 100mg of modafinil. Excipients in the tablet are: lactose, strach, pregelatinised maize, maicrocrystaline cellulose, croscarmellose sodium, providone and magnesium stearate (Medsafe, 2015).
Indications: Modavigil ® is indicated as a treatment for excessive daytime sleepiness associated with narcoplasy, obstructive sleep anoea/hypopnoea syndrome in order to improve wakefulness. Due to its wake- promoting effect it can be given to treat excessive sleepiness associated with moderate to severe chronic shift work sleep disorder where nonpharmacological intervention are unsuccessful or inappropriate (Schwartz 2005). It is use off label for an attention-deficit/hyperactivity disorder (ADHD), treatment of fatigue in Multiple sclerosis and other disease (Dana et al., 2012).
Contraindication: Modafinil is not recommended for use in patient with moderate to severe uncontrolled hypertension, or arrhythmia, associated with cardiovascular adverse effects, also those suffering from or have history of left ventricular hypertrophy, cor pulmonale, or of clinically significant signs of CNS stimulant-induced mitral valve prolapse (Including ischaemic ECG changes and chest pain)…

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