Cancer is one of the most important human health problems in the world. There is a global effort to make progress in new technologies that could overcome the inherent disadvantage of chemotherapy and efficiently destroy tumors without damaging the healthy body. The two most important goals of antitumor therapy are to detect cancer at primary steps, deliver medicinal active ingredients to the special sites with reducing of adverse effects and increase of the efficacy of an anticancer drug. One of the most common chemotherapeutic drugs is doxorubicin (DOX), that is anthracycline antibiotic which inhibits DNA and proteins synthesis. DOX indicates antitumor activity through inhibition of topoisomerase II; as a result, it inhibits the replication
