I learned from this activity that the dose-response curve is used to measure the relationship between the quantity of a substance (the dose) and its overall effect (the response).
I was able to recognize that dose and response are related by practicing the relationship on a graph. The dose is placed on the X-axis as the concentration of substance while the response is placed on the Y-axis as a percentage. In the example that we have in step 1, the dose that results in 50% mortality of subjects is called the LD50 or “50% Lethal Dose”). We also practiced how to determine the LD50 by locating where the curve equals 50%, then projecting down to the X-axis to find the corresponding dose. We also reviewed the four different shapes of a dose-response curve; S-curve, …show more content…
It is also interesting to learn that the dose-response curves use a logarithmic scale along the X-axis to represent values that span many “order of magnitude.” A value is one order of magnitude greater than another value when it is approximately ten times greater. A log scale accommodates large ranges by spacing order of magnitude equally along the axis. For example, doses might be as follows: 1, 3, 10, 30, 100, 300, 1000, 3000, and 10000 nM. When we convert these doses to logarithms (and slightly rounded), these values are equally spaced: 0.0, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, and 4.0 (What are dose-response curves, n.d.)
I also practiced in step 3 and 4 how to plot the data by dragging the data points to the correct location on the graph.
And finally, in step 5, I reviewed the generic dose-response curves, and how a curve means different things depending on the nature of the study. I was able to identify the dose associated with a particular percentage response by sliding the vertical bar left and right (Dose-Response Curves,
I was able to recognize that dose and response are related by practicing the relationship on a graph. The dose is placed on the X-axis as the concentration of substance while the response is placed on the Y-axis as a percentage. In the example that we have in step 1, the dose that results in 50% mortality of subjects is called the LD50 or “50% Lethal Dose”). We also practiced how to determine the LD50 by locating where the curve equals 50%, then projecting down to the X-axis to find the corresponding dose. We also reviewed the four different shapes of a dose-response curve; S-curve, …show more content…
It is also interesting to learn that the dose-response curves use a logarithmic scale along the X-axis to represent values that span many “order of magnitude.” A value is one order of magnitude greater than another value when it is approximately ten times greater. A log scale accommodates large ranges by spacing order of magnitude equally along the axis. For example, doses might be as follows: 1, 3, 10, 30, 100, 300, 1000, 3000, and 10000 nM. When we convert these doses to logarithms (and slightly rounded), these values are equally spaced: 0.0, 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, and 4.0 (What are dose-response curves, n.d.)
I also practiced in step 3 and 4 how to plot the data by dragging the data points to the correct location on the graph.
And finally, in step 5, I reviewed the generic dose-response curves, and how a curve means different things depending on the nature of the study. I was able to identify the dose associated with a particular percentage response by sliding the vertical bar left and right (Dose-Response Curves,