Difference Between Primary And Secondary Hyper-Algesia

Hyperalgesia is a response of nociceptors to a noxious stimuli. It is an increase of pain sensitivity. The noxious stimuli activates the nociceptive nerve fibres, which then generates impulses that travel to the spinal cord and in terms of the hyperalgesic process, these stimuli become amplified pain impulses that produce a diffuse pain. When the sensitivity of the nociceptors is increased, this results the increased formation and frequency of impulses moving along the efferent neurons to the central nervous system.
The secondary hyper-algesia is as same as the hyper-algesia, but the difference is the secondary hyper-algesia is more severe and more pain full. When the inflammation of tissue becomes ongoing without respite, the sensitivity increases.