Diclofenac is a proven drug has an anti-inflammatory, analgesic, and antipyretic effect. It was noticed that Diclofenac has an effective outcome in treating variety of acute and chronic inflammatory conditions. The action of diclofenac occurs via inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) which leads to inhibit the prostaglandin synthesis. Diclofenac can be administrated either oral, IV, or gel. The common side effects of diclofenac on GI are gas, indigestion, nausea, vomiting, diarrhea, constipations, ulceration, bleeding, etc. In addition, it can cause some cardiovascular effects as myocardial infarction, cardiovascular (CV) thrombotic events, and stroke. Moreover, other side effects can occur as headache, dizziness,
