Diabetic Foot Ulcer Summary

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Review of “A Clinical Trial of Integra Template for Diabetic Foot Ulcer”
Diabetic foot ulcer is happening due to complications involving the slow healing process as a result of the diabetes. The diabetic foot ulcer is cause by diabetes mellitus which increases risk for diabetic foot ulcer. (Driver et al 891) Diabetic foot ulcer can eventually lead to amputation if not treated or if it is too advanced. now there’s a way to treat foot ulcers using synthetic skin grafts. using a bilayer of silicone and collagen, it temporally covers that open area. This allows the wound to heal without the interference of constant dressings and cleanings.
Clinical were performed on patients on patient under the following inclusive criteria: “confirmed
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Tissue trauma causes injured tissue cell, the macrophages, mast cells and other release inflammatory chemicals which cause the capillaries to dilated and become very permeable. White blood cell and plasma fluid rich in clotting proteins, antibodies, and other substances seep in to the injured area. The leaked clotting proteins construct a clot, which stops the loss of blood, holds the edges of the wound together, and effectively wall in or isolate the injured area, preventing bacteria, toxins, or other harmful substances from spreading to surrounding tissues. The part that clot exposed it the air quickly dries up and hardens, forming a scab. The inflammatory events leave behind excess fluid, bits of destroyed cells and other debris, which is removed via lymphatic vessels or phagocytized by macrophages. Organization restores the blood supply. Even while the inflammatory process is going on, the first phase of tissue repair, called organization, begins. During organization, the blood clot is replaced by granulation tissue, a delicate tissue composed of several elements. It contains capillaries that grow in from nearby area and lays down a new capillary bed. Granulation tissue is actually named for these capillaries, which protrude nub-like from its surface, giving it a granular appearance. These capillaries are fragile and bleed freely, as we see when someone picks a scab. Proliferating fibroblasts in granulation tissue produces growth factors as well as new collagen fibers to bridge the gap. Some of these fibroblast have contractile properties that allow them to pull the margins of the wound together or to pull existing blood vessels into the healing wound. As organization proceeds, macrophage digests the original blood clot and the collagen fibers deposit continues. The granulation tissue, destined to become scar tissue is highly resist to infection because it produces bacteria-inhibiting substances…once enough matrix has accumulated

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