Describe The Immunopathogenesis Of Rheumatoid Arthritis Essays
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Rheumatoid arthritis (RA) is a chronic, progressive systematic disease that affects many tissues and involves cartilage and bone destruction by primarily attacking synovial joints (McInnes, 2011). It is accompanied by stiffness and inflammation of the joints and is often characterised by deformities which can become disabling. Immunopathogenesis is the course of development the disease takes, during which an immune response or the products of an immune reaction are involved (Farlex, 2007).
The aetiology of RA remains unknown and the prognosis guarded, it is assumed to be related with self-antigen or could be microbial (McInnes, 2011). There is a higher chance of having RA if one of your family members endures it and so the disease initiation it thought to be related in many cases with genetic predisposition (e.g. if inherited antigen subtype called HLA-DR4 you have a greater chance of development). We investigate the pathogenesis of RA by defining the behaviour of the molecular target. It affects the lining of synovial joints causing severe swelling or turgescence which is excess synovial fluid production. Ankyloses takes place which is where inflammation thickens the synovial fluid which eventually destroys cartilage and bones in joints. The peak onset of the disease falls between the ages of 40-60 and it can bring devastating pain to these individuals.
The event of most significance in leading any immune response…