Common symptoms of Osteoarthritis are stiffness, pain and joint dysfunction (Better Health
Channel, 2016, para. 5). Glucosamine is an effective treatment for Osteoarthritis (Arthritis
Research, 2005, para. 3). The double-blind randomized clinical trial (RCT) conducted by
Hamid Reza Arti and Mohammad Ebrahim Azemi in 2012 drew attention to Alendronate.
Alendronate is known to have healing properties and known to treat Osteoporosis
(MedlinePlus, 2015, para. 1). The aim of the study was to compare the efficacy of
glucosamine alone and the combination of glucosamine and alendronate administration to
treat knee osteoarthritis in older adults aged between …show more content…
Participants symptoms were recorded via
the WOMAC questionnaire.
The main findings of the study supported the hypothesis. Bone spurs (Osteophytes) are also
known mechanisms of joint pain and causes a limits to normal joint range of movement or
stiffness (Felson et al., 2004, p. 100). Glucosamine is known to aid in the growth,
maintenance and repair of joint cartilage (Arthritis Foundation, 2016, para. 4). Osteophytes
are also prevented from forming in particular surfaces where they would normally cause
participants osteoarthritic pain. Glucosamine intervention reduced the pain and stiffness in
the majority of participants from Group 1 and Group 2 for this reason.
However, the addition of alendronate to glucosamine in Group 1 yielded better results in
the other areas that were tested. Firstly, Bone Mineral Density (BMD) improved in Group 1.
Only slight improvement was made in Group 2. This supports the hypothesis because Group
1 were administered a combination of glucosamine and alendronate and therefore it
appears Alendronate leads to an improved intervention for BMD than glucosamine alone.
Secondly, The function of joints in Group 1 improved after 12 weeks. Whereas there …show more content…
Vitamin D and Calcium’s healing properties, it’s unlikely that Glucosamine and/or
Alendronate were able to achieve the pain and joint stiffness reductions alone. Therefore,
the degree in which Vitamin D and Calcium impacted the findings of the study is unknown. A
suggestion to avoid this co-intervention bias is to not administer vitamin D and/or Calcium
or any other additional healing agent to participants. This is likely to reduce the likelihood
that the results were impacted by the additional healing agents.
External validity refers to the degree results of the participants (sample) can be generalised
to the broader population. The more representative of the population the sample is the
more confidently the reader can generalise.
The range of ethnicity of participants is not accurately reflected in the study. If the
participants selected were of an urban location of high socioeconomic status with good
dietary habits and access to regular health care, then it is likely that the findings would not
be replicated for people of remote locations of low socioeconomic status with poor