After oral administration of cyclosporine (as NEORAL), the time to peak blood concentrations is 1.5 to 2 hours. Highand low-fat meals decreases the rate and extent of absorption. Cyclosporine is metabolized in the liver by CYP3A and to a lesser degree by the gastrointestinal tract and kidneys. Cyclosporin is highly bound to erythrocytes and plasma proteins[1]. Approximately 80%of cyclosporine plasma is bound to lipoproteins.Patient's haematocrit and lipoprotein profile affect the distribution of cyclosporin in blood[2]. Cyclosporine and its metabolites are excreted principally through the bile into the feces, with only about 6% being excreted in the urine. Only 0.1% of cyclosporine is excreted unchanged in urine[2].
After oral administration
After oral administration