COPD Case Study

INTRODUCTION The modern view of COPD suggests that this - a progressive disease characterized by an inflammatory component, bronchial obstruction and structural changes in the lung tissue. And a significant role in the pathogenesis plays a variation of the immune reactivity. It is known that activation of immune reactions in COPD mediated effects on molecular cell systems a wide range of mediators, primarily cytokines that regulate the immune reactivity of the organism. [1] Established that are the main producers of cytokines and T-lymphocytes are activated monocytes / macrophages [2, 3]. Secreted they actively act as mediators in the inflammation, as a result of performing a number of protective functions [4,5]. In this connection, it is necessary to study the levels of cytokines that influence the development and course of chronic inflammation in the body [6].

Cytokines are physiological intracellular signaling proteins that many cells in the body are formed. Interleukin-6 act an essentially pro-inflammatory cytokine and has been involved to show an aspect in the systemic inflammation in patients along chronic obstructive lung disease COPD [7].however Human IL-8 is a compelling Chemoattractant and stimulant like Eosinophilic cells, As the main representative of the CXC Chemokines, is on the in vivo and vitro …show more content…
Favorable results drug, on the other hand actual limited by the small track (six weeks in each branch with 2 extra washes) and the very limited number of patients 42 in total [16]. Similar year In a wide, Multicentric trial Study in Primary Care, double-blind RCT 3 year track, trying to assess the number of exacerbations and Spirometric parameters in 3 branches Fluticasone Propionate, Acetylcysteine and placebo, with 286 patients. I do not found beneficial effect in all of the treatments