3. Concurrent drug therapy issues:
• Concomitant use with opioids [US Boxed Warning]: Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limits dosages to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.
• Concomitant use with opioids [US Boxed Warning]: Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limits dosages to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.