Introduction: With a complex aetiopathogenesis, IBD has been a burden and rising worldwide. Inflammatory Bowel Disease refers to chronic and relapsing inflammatory disorders which two main different disease include Crohn’s Disease and Ulcerative Colitis. In 1932 by Drs Burrill Crohn, Gordon Oppenheimer, and Leon Ginzburg described as an idiopathic transmural chronic inflammatory disorder affecting the gastrointestinal tract. In 1875 by Drs Wilks and Moxon first described and identified UC (ulcerative colitis) as noninfectious cause[1]. Some of the suspected etiology including life style, immune factors, gut flora, environmental factors, and genetic variation are strongly believed to be key holder. However, despite of enormous studied still
