Compare And Contrast Aptiom And Phenytoin

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Aptiom and Phenytoin may both be anticonvulsants, yet they have many points of contrasting variation which exemplify their individual advantages and disadvantages. For example, they have differing amounts of clinical research, drug therapy regimen variance, and cost differences that make the each drug distinct and highly distinguishable from the other. Phenytoin was first synthesized in 1908 and was approved by the FDA in 1939 (Ogbru, n.d). Since then, it has become one of the most commonly used antiepileptic medications in North America. An extensive amount of careful scientific trials has been done in a great number of patients (Epilepsy Foundation, n.d). It is best used to treat partial-onset seizures, but has value in treating tonic-clonic …show more content…
It costs approx $720.00 for thirty, 800mg tablets compared to $136.00 for the equivalent amount the brand name Phenytoin, Dilantin. Generic brands of phenytoin are even more inexpensive. According to Gregory L. Barklet, Chair of the Epilepsy Foundation’s advisory board and clinical vice chair of neurology at Detroit Henry Ford Hospital, “ The issue with phenytoin is it is the single most difficult anticonvulsant drug to use because it has very different metabolism than most medicines – small changes in dose result in wild swings in metabolism.” As a result of this, even small differences between Dilantin and generic name Phenytoin can cause huge clinical effects if a patient decided to switch from the brand name to a generic cheaper brand (DeNoon, …show more content…
Considering that both drugs are antiepileptics, they share many of the same drug interactions. Some of the most common include interactions with birth control and when used with other antiepileptics simultaneously. Since Aptiom and Phenytoin both trigger the P-450 system, they alter the metabolic rate of estrogen and binding of progesterone that is present in oral contraceptives. This limits the amounts of estrogen and progesterone in the blood, leading to a major decrease in effectiveness of the contraceptives being taken (Aschenbrenner, 2009; Dilantin.com). It is important to note that since Aptiom and Phenytoin both induce the Cytochrome P-450 system, they will alter the metabolism of many drugs – not just oral contraceptives. When antiepileptics are taken alone, there is a risk for increased suicidal ideations or attempts. However, when a patient is taking Aptiom or Phenytoin alongside another antiepileptic, there is an even greater risk for suicidal thoughts or attempts of suicide compared to if they were taken alone (aptiom.com; Aschenbrener,

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