Clostridium Difficile Analysis

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Clostridium difficile is a gram-positive anaerobic bacillus that forms spores and it is known as the most common cause of hospital-acquired diarrhea. Gastric acid was not believed to be important in protection agent against C difficile infection due to acid-resistant spores being allegedly the main vector of transmission. This theory has been challenged by numerous studies that have found a higher risk of C difficile infection in PPI users. PPIs may increase the risk of C difficile infection by increasing the capability of the spores to convert into a vegetative state and survive in the lumen of the stomach. Studies have shown a strong statistical correlation between PPI use and C. difficile infection. Experimental evidence suggests that

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