Congenital Insensitivity Essay

This disorder is when someone cannot and never has had the ability to perceive or feel any sort of pain done to their body. People with Congenital Insensitivity to Pain although unable to feel pain, can feel the difference between hot, cold, and dull and sharp, but cannot feel if something is burning them. People with this disorder also have very overt autonomic symptoms, so they tend to show a lot of their actions that are supposed to be involuntary. Congenital Insensitivity is a genetically transmitted disorder, also known as hereditary sensory and autonomic neuropathy type four. When both parents carry the gene mutation, there is a 25% chance the child will inherit the disorder during the pregnancy of the mother. Congenital insensitivity is causes by a mutation in the SCN9A gene, and even the slightest mutation of the gene leads to the gene not being able …show more content…
Fanconi and Ferrazzini in 1957 saw an affected pair of siblings, brother and sister, with parents descending from the same ancestors, which most likely meant there would be autosomal recessive inheritance, (because of the issue with the same genes) which when both copies of the gene are mutated. Silverman and Gilden in 1959 describe a family with the same parental status, except two out of the eight children were affected. The reoccurring pattern was that the parents of the affected children were coming from the same ancestors, which is also known as interbreeding between humans, when two humans, for example, brother and sister decide to have a child, or any two people related in any way decide to have a child, run the risk of their child potentially inheriting a recessive genetic