Chronic psychological stress and animal models of IBD
Like human, when Some animals are exposed to chronic stress, they may grow intestinal inflammation. Cotton top tamarins have high chance to develop a colitis similar to UC when exposed to prolonged stress of imprisonment, though remission occurs after returning to the natural living atmosphere [53]. Similarly, fatal colitis may also be seen in Siamese gibbons when kept in captivity [54].
As in humans, experimental models of psychological stress have been established in order to explain the fuction of psychological stress in animal models of IBD. A duration restraint stress, where movement of animals is limited by binding gently, is the commonest method used to produce acute stress in the …show more content…
Rats exposed to restraint stress for four days before induction of colitis by 2,4,6-trinitrobenzenesulfonic acid (TNBS) [56]. Restraint stress, when no other stimuli exist, induces partial re-stimulation of mucosal inflammation in rats, which, had recovered from TNBS colitis six weeks earlier; though no inflammatory changes were detected on the microscope, rise in colonic myloperoxidase was seen. [57]. A duration of restraint stress decreased the TNBS dose needed to re-stimulate colitis in mice, which had recovered from TNBS colitis eight weeks previously [58]. This vulnerability was interchangeable between mice by a population of CD4 rich lymphocytes taken from the mesenteric lymph nodes as well as the spleen, establishing that stress induced re-stimulation depends on the existence of important immune cells. Though recipient mice did not induce IBD soon, they needed a smaller TNBS dose in presence of restraint stress to develop mucosal ulceration than did controls.
Chronic stress seems to make an animal with colitis more susceptible to the effects of acute stress. Also, a adult rats that went through long-term maternal maternal separation previously and which were then exposed to many unescapable foot shocks, experienced more severe dextran sodium sulphate induced colitis than did controls
Like human, when Some animals are exposed to chronic stress, they may grow intestinal inflammation. Cotton top tamarins have high chance to develop a colitis similar to UC when exposed to prolonged stress of imprisonment, though remission occurs after returning to the natural living atmosphere [53]. Similarly, fatal colitis may also be seen in Siamese gibbons when kept in captivity [54].
As in humans, experimental models of psychological stress have been established in order to explain the fuction of psychological stress in animal models of IBD. A duration restraint stress, where movement of animals is limited by binding gently, is the commonest method used to produce acute stress in the …show more content…
Rats exposed to restraint stress for four days before induction of colitis by 2,4,6-trinitrobenzenesulfonic acid (TNBS) [56]. Restraint stress, when no other stimuli exist, induces partial re-stimulation of mucosal inflammation in rats, which, had recovered from TNBS colitis six weeks earlier; though no inflammatory changes were detected on the microscope, rise in colonic myloperoxidase was seen. [57]. A duration of restraint stress decreased the TNBS dose needed to re-stimulate colitis in mice, which had recovered from TNBS colitis eight weeks previously [58]. This vulnerability was interchangeable between mice by a population of CD4 rich lymphocytes taken from the mesenteric lymph nodes as well as the spleen, establishing that stress induced re-stimulation depends on the existence of important immune cells. Though recipient mice did not induce IBD soon, they needed a smaller TNBS dose in presence of restraint stress to develop mucosal ulceration than did controls.
Chronic stress seems to make an animal with colitis more susceptible to the effects of acute stress. Also, a adult rats that went through long-term maternal maternal separation previously and which were then exposed to many unescapable foot shocks, experienced more severe dextran sodium sulphate induced colitis than did controls