Abstract
The aim of the present study was to investigate the effects of Cichorium intybus on lipid peroxidation activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in experimental diabetic cardiomyopathy (DCM). Diabetic cardiomyopathy was induced by single intraperitoneal injection of STZ (40mg/kg) combined with high energy intake in rats. Seed extract of Cichorium intybus (CIE) (250mg/kg & 500mg/kg) was administered orally once a day for 3 weeks. Phytochemical investigations of seed extract revealed the presence of some active ingredients such as alkaloids, tannins, saponin, phenols, glycosides, steroids, terpenoids and flavonoids. An elevation of the …show more content…
The long term complications of diabetes are of great concern. However, there is an increasing recognition that diabetes patients suffer from an additional complication termed diabetic cardiomyopathy (DCM). Diabetic cardiomyopathy, as an independent diabetic cardiaovascular complication, is characterized by hypertension or valvular heart disease, the myocardial dysfunction in the absence of coronary artery disease. Past investigations reported that the pathophysiology of DCM results in increment of lipid accumulation, hyperglycemia, excessive generation of reactive oxygen species, cardiac inflammation and accumulation of cardiac fibrosis 2,3. The existence of oxidative stress has been postulated in patients with diabetes. Lipid peroxidation (LPO) has been implicated in the pathogenesis of naturally occurring or induced diabetes 4. Oxidative stress may be increased in diabetes owing to hyper-production of reactive oxygen species (ROS), such as O2., OH. & H2O2 and/or a deficiency in the antioxidant defense system. In diabetic state free radicals simply formed during and dole out an important role in the generation of diabetic complications 5. The cytotoxic action of STZ is allied with the generation of reactive …show more content…
Series of genes expressed gets stimulated by activated macrophages during inflammation in host defense, which conclude the release of different inflammatory mediators, cyclooxygenase-2, nitric oxide, pro inflammatory cytokines etc.10. Therefore, to prevent, delay or treat the above ailment inflammation should be suppressed.
The aim of the present study was to investigate the effects of Cichorium intybus on lipid peroxidation activities of both enzymatic and non-enzymatic antioxidants, inflammatory mediators, myocardial enzymes and histopathology of cardiac tissues in experimental diabetic cardiomyopathy (DCM). Diabetic cardiomyopathy was induced by single intraperitoneal injection of STZ (40mg/kg) combined with high energy intake in rats. Seed extract of Cichorium intybus (CIE) (250mg/kg & 500mg/kg) was administered orally once a day for 3 weeks. Phytochemical investigations of seed extract revealed the presence of some active ingredients such as alkaloids, tannins, saponin, phenols, glycosides, steroids, terpenoids and flavonoids. An elevation of the …show more content…
The long term complications of diabetes are of great concern. However, there is an increasing recognition that diabetes patients suffer from an additional complication termed diabetic cardiomyopathy (DCM). Diabetic cardiomyopathy, as an independent diabetic cardiaovascular complication, is characterized by hypertension or valvular heart disease, the myocardial dysfunction in the absence of coronary artery disease. Past investigations reported that the pathophysiology of DCM results in increment of lipid accumulation, hyperglycemia, excessive generation of reactive oxygen species, cardiac inflammation and accumulation of cardiac fibrosis 2,3. The existence of oxidative stress has been postulated in patients with diabetes. Lipid peroxidation (LPO) has been implicated in the pathogenesis of naturally occurring or induced diabetes 4. Oxidative stress may be increased in diabetes owing to hyper-production of reactive oxygen species (ROS), such as O2., OH. & H2O2 and/or a deficiency in the antioxidant defense system. In diabetic state free radicals simply formed during and dole out an important role in the generation of diabetic complications 5. The cytotoxic action of STZ is allied with the generation of reactive …show more content…
Series of genes expressed gets stimulated by activated macrophages during inflammation in host defense, which conclude the release of different inflammatory mediators, cyclooxygenase-2, nitric oxide, pro inflammatory cytokines etc.10. Therefore, to prevent, delay or treat the above ailment inflammation should be suppressed.